The award for the most watched drug trial in the past couple of years goes to nsi-189. This would be mildly amusing if this wasn’t true, but it’s not a joke. Trials for this nootropic is expected to end by December of this year, and it has all the attention because of its purpose – it will supposedly treat depression. We say supposedly because everybody’s waiting for the official kudos from the scientific community, but the consumers have already confirmed that it works.
What is NSI-189? Summary
Benzylpiperazine-aminopyridine is nsi-189’s chemical background and it should become a game-changer in treating depression. NSI-189 is a novel neurogenic antidepressant. This nootropic is not a fugazi, and it’s currently undergoing the second phase of clinical evaluation by Neuralstem. What makes this nootropic possibly one of the best supplements out there are the trials that showed a 20% volume increase in the mouse’s hippocampus. Hippocampus handles mood and consolidation of information from short-term to long-term memory. Every dose of nsi 189 would show a positive improvement in the adult mice’s depression model. Now, this is where it gets exciting – this chemical compound actually stimulates the growth of new neurons in the hippocampus. In theory, you’d hardly get depressed if you’re using NSI-189 because the disease would now have to overpower a much larger part of your brain than before you started taking them.
NSI-189 Mechanism of Action
There’s a theory out there: the smaller the hippocampus, the bigger the risk for humans to get depression disorder. Why is this important? If this part of the brain suffers the damage caused by Alzheimer’s, the results are disorientation and memory in the first blow, and further complications would include hypoxia (oxygen levels deficit to the brain) and encephalitis. Another result of the NSI’s mechanism of action is an anti-stress effect. Those who were impatient and tried this nootropic said they felt strange and with no reaction in stressful situations. This effect may not be to everyone’s liking. Some people claim that controlled anger and exaggeration as a response give them the necessary edge in crucial situations. However, it seems this particular supplement has the power to transform you into a Buddha.
Price and Availability
The main problem with getting this nootropic is that the majority of sites that guarantee the quality and contents are only selling to labs, not consumers. That doesn’t mean it’s impossible to buy it, just limits the number of sources. The stock runs out fast, that’s another problem. Once people find a reliable legit site that deals with NSI-189, they buy every single pack quick fast. Various different sources can be easily found if you want to buy nsi-189. Just be sure to check the quality first. If you want to buy it on eBay check out seller’s feedbacks regarding quality. There are numerous NSI-189 sellers that have 99% positive feedback, but most of the buyers are praising about fast shipping.
NSI-189’s Side Effects
Most nootropics I’ve tried have been virtually free of adverse effects. NSI-189 did cause side effects which convinced me that it was doing something. I experienced these side effects:
- intermittent peripheral neuropathy (transient loss of sensation in the hands and feet)
- increased appetite
- increased dietary preference for sugar (sweet tooth)
- exercise intolerance
- post-exercise headaches
- decreased motivation
- Fugue states where my inner dialogue was absent
Some of these side effects will seem like a major burden. But they were more than offset by the benefits of NSI-189:
- increased sleep quality and increased sleep duration
- decreased anxiety
- decreased social inhibitions
- increased laughter
- increased playfulness
- decreased physical sensitivity to pain
- decreased blood pressure (I’m normally hypertensive)
- decreased heart rate
- an almost disconcerting lack of stress
- mood stability