Health supplements seem to be very popular among athletes and bodybuilders. There are a plethora of health supplements available on the market, but the ones that see the most use among health nuts is GW 501516 or Cardarine.
The reason behind its spike in popularity is the fact that itâ€™s known to combat cardiovascular diseases and maintain good blood cholesterol in the human body. Even with numerous controversies surrounding the drug, they havenâ€™t hindered its rise in popularity among its consumers.
Now, let us take a deeper look into Cardarine.
What is Cardarine?
As mentioned in the start of the article, Cardarine grants numerous health benefits to the user. However, it is mainly used for weight loss. The way it all work is it binds t the PPAR receptor in your body which affects our bodyâ€™s metabolism as a result. This is common among drugs that target the PPAR receptor.
To put it simply, using Cardarine increases your bodyâ€™s metabolic rate which means that youâ€™ll burn more fat on a daily basis as well as improve your cardiovascular endurance. Ligand Pharmaceuticals and GlaxoSmithKline were the first to synthesize Cardarine in the early 1990s.
The theory behind this drug is that it could help prevent obesity and even cure diabetes. At first, the results found were very promising, however, further trials showed that in higher doses, Cardarine caused cancer in rats, which led them to stop further pursuing the Cardarine SARM.
How to Take Cardarine
In order to get the most out of the drug, 10mg per day should be enough. Anything more than 20mg, and youâ€™ll be putting your health at risk. With that said, you can still get very decent results with doses as low as 10mg.
Itâ€™s recommended that you start small with 10mg. That should be enough for most people. However, if you feel like you need a bigger boost, you can pump it up to 15-20mg per day, but nothing more. When it comes to when you should dose during the day, it shouldn’t really matter as the drugâ€™s half-life is around 24 hours long.
However, some users have said that dosing it before the workout by 30-60 minutes can give a more notable boost, so keep that in mind. With that said, your priority should be making sure that you take the drug on a daily basis. I
f you manage to stay consistent, then the time you take the drug should not matter, itâ€™s a matter of personal preference.
Cardarine cycle should last you anywhere between 8 and 16 weeks. Beyond that point, you will begin to experience diminishing returns. In that case, itâ€™s advised that you take a month off from the drug, then start another cycle after that.
Cardarine isn’t known to have adverse side effects, nor is it suppressive by any means. Nonetheless, itâ€™s recommended to cycle it simply to avoid reaching the point where you start noticing those diminished returns.
Cardarine Fat Loss Benefits
As mentioned in the beginning, Cardarine is considered the best SARM for fat loss, and it does its job wonderfully as it contains chemical compounds that function in the differentiation phase of adipocytes or fat cells.
Cardarine acts pretty much like growth hormone. It generates pro-inflammatory markers in fat tissue and reduces the activity of genes that intervene in lipogenesis, which gives the organism the ability to prevent fatty acid cahins from being stored as fat.
It has been found that in animals, Cardarine also decreased glucose output by the liver and increased insulin sensitivity. It was also found to improve obesity resistance in mice by driving muscle fiber development.
Overall, the Cardarine fat loss results are well-recognized in the bodybuilding and fitness industry.
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Other Cardarine Benefits
There are numerous Cardarine benefits besides fat loss, mainly:
Stamina Improvement and Muscle Growth
When PPAR is activated by Cardarine, muscle fibers development is increased in mice. This means that physical performance is increased. Not only that, but the mice also seemed to run for twice as long without stopping which indicates improved endurance.
A study from Scientific Reports published in 2015 by Wei Chen, Ph.D. has shown that a significant increase in the PPAR gene in slow twitch fibers increases oxygen usages thus dramatically increasing stamina. The improved strength was observed in lab mice with a healthy oxygen supply and those with oxygen restrictions which provided damning evidence that GW501516 does indeed target skeletal muscle endurance and recovery time and enhances both of them.
Heart Endurance Improvement
Cardarine has some great advantage for the heart. One of them is the fact that it can prevent oxidative damage in the heart. Cardarine also decreases both the severity and risk of atherosclerosis. It also increases the levels of nitric oxide with protect against the latter.
Not only that, but in mice, it was shown to reduce relisions and inflammations associated with atheroclerosis. It also increases VEGF production from blood vessel cells, which stimulates blood vessel and cell formation.Animal studies also showed that Cardarine caused a decrease of triglycerides and an increase of HDL cholesterol thus reducing the risk of cardiovascular disease.
Liver Damage Prevention
Given that Cardarine accentuates PPAR, it results in the liver switching its vitality source to fatty acid rather than glucose. When administered on mice, Cardarine IL-6, which could help avert insulin protection in liver cells. It can also revert liver damage caused by high fructose consumption. Cardarine can also improve nonalcoholic liver issue in mice.
Cardarine can help prevent oxidative stress in the brain, thanks to the stimulation of PPAR which helps in the development of new nerve cells which can fend off toxins. Caradarine also prevent oxidative stress in the blood vessels by assisting the brain blood vessels.
Diabetes Risk Reduction
One of the amazing results that the GSK studies mentioned before found, is the fact that Cardarine is so effective at protecting from diabetes, that it can even do its job regardless of the diet the user is on. As proven by giving 2 groups of rats very unhealthy diets and then giving one group Cardarine.
The study found that the group with that wasn’t given Cardarine had a very high rate of diabetes, which is natural given the unhealthy diet. On the other hand, the group that was given Cardarine saw a decrease in the rate of diabetes, which is a shocker. This study has shown that Cardarine keeps users from gaining body fat regardless of the diet theyâ€™re on.
Cardarine Before and After
Itâ€™s important to acknowledge the fact that the results of Caradarine use can vary from person to person depending on the goals that you want to reach. Given that Cardarine has so many uses, it really boils down to how you intend to use it.
The majority of people lose about 5-10lbs of fat, but the results may differ depending on the body type and other factors. With that said, what should you expect fro Cardarine? To answer that question, Cardarine should boost insulin sensitivity along with decreased glucose output by the liver, and, of course, body fat loss.
Cardarine should also help you feel more energetic even if youâ€™re on a strict diet. You should also notice an increase in stamina and endurance, and if you maintain a healthy diet you should notice increased muscle growth.
Cardarine Side Effects
While there havenâ€™t been any reports of any side effects from Cardarine studies, that does not mean that the drug has completely no side effects to mention.
For one, the drug has only been tested on healthy subjects, so its effect on more isolated cases are yet to be known. We also still donâ€™t know if the drug causes any long term effects or has any long term ramifications to mention.
The fact that there are no notable side effects of Cardarine goes to show why it has gained so much popularity overtime. The list of positives way outnumbers that of the negatives.
Cardarine has been even found to reverse diabetes, obesity, Dyslipidemia along with a plethora of other diseases.
Can Cardarine Cause Cancer?
Weâ€™ve mentioned before that Cardarine would cause cancer in high doses according the study conducted by Ligand and GSK. The study involved injecting mice with 2000mg of Cardarine on a daily basis on the span of 2 years.
Not only is that a ridiculous amount to consume, but even then, people usually go on cycle of 8-16 weeks which doesn’t even come close to a year, let alone 2.
As of 2018, there havenâ€™t been any report of cancer in consumers, none.
When it comes to fat loss, Cardarine is one of the most effective SARMS in the market so far. It also increases stamina, endurance, muscle growth, can even prevent diabetes and several other diseases with minimal side effects.
The Cardarine bodybuilding benefits are countless, and that is why it has gained so much popularity in the fitness industry.